7,12-dimethylbenz[a]anthracene

**7,12-dimethylbenz[a]anthracene (DMBA)** is a polycyclic aromatic hydrocarbon (PAH) that is a potent laboratory carcinogen[1][2][3]. DMBA is used in biomedical research to induce tumors, such as mammary and skin cancers in animal models, due to its ability to be metabolically activated by microsomal enzymes into diol epoxide intermediates, which covalently bind to DNA and initiate carcinogenesis[2]. It is found in tobacco smoke and is notable as a mutagen, teratogen, and flammable solid[1][2]. DMBA exhibits selectivity for necrosis and hemorrhaging in adrenal gland tissues and inhibits plasma alkaline phosphatase activity, likely through formation of charge transfer complexes with biomolecules[2].

Other names

7,12-dimethylbenz(a)anthracene7,12-Dimethylbenzanthracene7,12-dimethyltetraphene9,10-Dimethyl-1,2-benzanthracene7,12-Dimethylbenzo[a]anthracene6,7-Dimethyl-1,2-benzanthracene1,4-Dimethyl-2,3-benzphenanthreneBenz(a)anthracene, 7,12-dimethyl-9,10-Dimethylbenz[a]anthraceneDimethylbenzanthraceneMFCD00003600MFCD-00003600MFCD 00003600BRN 1912135BRN1912135BRN-1912135CHEBI:254496NSC408823NSC-408823NSC 408823DTXSID1020510DTXSID-1020510DTXSID 1020510F05B6S0395F-05B6S0395F 05B6S0395DMBAnSKL149SKL-149SKL 149N-BENZYLDIMETHYLAMINE